Jump to main content
Jump to site search


A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels

Abstract

In this study, we designed a novel biomaterial ink platform based on hydrophilic poly(2-ethyl-2-oxazine) (PEtOzi) specifically for melt electrowriting (MEW). This material crosslinks spontaneously after processing via dynamic Diels-Alder click chemistry. These direct-written microperiodic structures rapidly swell in water to yield , thermoreversible hydrogels. These hydrogesl are robust enough for repeated aspiration and ejection through a cannula without structural damage, despite their high water content of 84 %. Moreover, the scaffolds retain functional groups for modification using click chemistry and therefore can readily be covalently functionalized as demonstrated using fluorophores and peptides to facilitate visualization and cell attachment. The PEtOzi hydrogel developed here is compatible with confocal imaging and staining protocols for cells. In summary, an advanced material platform based on PEtOzi is reported that is compatible with MEW and results in functionalizable chemically crosslinked microperiodic hydrogels.

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Oct 2019, accepted on 02 Dec 2019 and first published on 02 Dec 2019


Article type: Communication
DOI: 10.1039/C9MH01654F
Mater. Horiz., 2019, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels

    D. Nahm, F. Weigl, N. Schaefer, A. Sancho, A. Frank, J. Groll, C. Villmann, H. Schmidt, P. Dalton and R. Luxenhofer, Mater. Horiz., 2019, Accepted Manuscript , DOI: 10.1039/C9MH01654F

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements