Wound Dressing Change Facilitated by Spraying Zinc Ions
It is a tough task in clinic to remove and refuel the dressing. Inspired by the chemical structure of mussel adhesive protein (MAP), an injectable dopamine (DOPA)-based adhesive hydrogel was constructed as wound healing dressing which could be easily replaced by spraying zinc ions. A hyperbranched polymer named HB-PBAE was synthesized by Michael addition reaction among dopamine (DOPA), poly(ethylene glycol) diacrylate (PEGDA700), and pentaerythritol triacrylate (PETA). The DOPA-based adhesive hydrogel was fabricated by mixing HB-PBAE, poly(1-vinylimidazole) (PVI) and gelatin solution, followed by adding Fe3+. Intriguingly, spraying Zn2+ solution could result in a rapidly reduced adhesive strength and sharply increased strength. Importantly, the adhesive addressing can reduce the damage during dressing change in a rat wound bed and accelerate wound healing process. The metal ion facilitating dressing change might provide a novel concept in designing wound dressing.