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Wound dressing change facilitated by spraying zinc ions

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Abstract

It is a tough task in the clinic to remove and refresh dressings. Inspired by the chemical structure of mussel adhesive proteins (MAP), an injectable dopamine (DOPA)-based adhesive hydrogel was constructed as a wound-healing dressing that could be easily replaced by spraying zinc ions. A hyperbranched polymer named HB-PBAE was synthesized by a Michael addition reaction between dopamine (DOPA), poly(ethylene glycol) diacrylate (PEGDA700), and pentaerythritol triacrylate (PETA). The DOPA-based adhesive hydrogel was fabricated by mixing HB-PBAE, poly(1-vinylimidazole) (PVI) and gelatin solution, followed by adding Fe3+. Intriguingly, spraying Zn2+ solution resulted in rapidly reduced adhesive strength and sharply increased strength. Importantly, the adhesive dressing reduced damage during changing the dressing in a rat wound bed and accelerated the wound-healing process. This metal ion-facilitated dressing change might provide a novel concept in the design of wound dressings.

Graphical abstract: Wound dressing change facilitated by spraying zinc ions

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Publication details

The article was received on 12 Aug 2019, accepted on 06 Nov 2019 and first published on 06 Nov 2019


Article type: Communication
DOI: 10.1039/C9MH01255A
Mater. Horiz., 2020, Advance Article

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    Wound dressing change facilitated by spraying zinc ions

    T. Xie, J. Ding, X. Han, H. Jia, Y. Yang, S. Liang, W. Wang, W. Liu and W. Wang, Mater. Horiz., 2020, Advance Article , DOI: 10.1039/C9MH01255A

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