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Wound Dressing Change Facilitated by Spraying Zinc Ions

Abstract

It is a tough task in clinic to remove and refuel the dressing. Inspired by the chemical structure of mussel adhesive protein (MAP), an injectable dopamine (DOPA)-based adhesive hydrogel was constructed as wound healing dressing which could be easily replaced by spraying zinc ions. A hyperbranched polymer named HB-PBAE was synthesized by Michael addition reaction among dopamine (DOPA), poly(ethylene glycol) diacrylate (PEGDA700), and pentaerythritol triacrylate (PETA). The DOPA-based adhesive hydrogel was fabricated by mixing HB-PBAE, poly(1-vinylimidazole) (PVI) and gelatin solution, followed by adding Fe3+. Intriguingly, spraying Zn2+ solution could result in a rapidly reduced adhesive strength and sharply increased strength. Importantly, the adhesive addressing can reduce the damage during dressing change in a rat wound bed and accelerate wound healing process. The metal ion facilitating dressing change might provide a novel concept in designing wound dressing.

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Publication details

The article was received on 12 Aug 2019, accepted on 06 Nov 2019 and first published on 06 Nov 2019


Article type: Communication
DOI: 10.1039/C9MH01255A
Mater. Horiz., 2019, Accepted Manuscript

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    Wound Dressing Change Facilitated by Spraying Zinc Ions

    T. Xie, J. Ding, X. Han, H. Jia, Y. Yang, S. Liang, W. Wang, W. Liu and W. Wang, Mater. Horiz., 2019, Accepted Manuscript , DOI: 10.1039/C9MH01255A

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