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Engineering proteinosomes with renewable predatory behaviour towards living organisms

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Abstract

Communication is a fundamental feature of life, and all living organisms interact actively with their surroundings to better their chance of survival through the coordination of group behavior. To develop mutual interactions between an artificial cell and living organism, we constructed a positively charged thermo-sensitive proteinosome with loaded L-arginine modified chitosan oligosaccharide as an antimicrobial in the hydrogel-based core domain, and then by controlling the temperature and ionic strength we demonstrate that changes in both the hydrophobicity and the electrostatic attraction allowed the constructed proteinosomes to show a programmed interaction with the living organism E. coli, including capture, aggregation induced self-suicide, release, and then the renewal of the proteinosomes. It is anticipated that our results will contribute to the development of the communication behaviours within artificial cell and living organism hybrid microsystems, and lay a foundation for further engineering artificial cell models towards biology inspired materials.

Graphical abstract: Engineering proteinosomes with renewable predatory behaviour towards living organisms

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Publication details

The article was received on 25 Jun 2019, accepted on 09 Aug 2019 and first published on 09 Aug 2019


Article type: Communication
DOI: 10.1039/C9MH00976K
Mater. Horiz., 2019, Advance Article

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    Engineering proteinosomes with renewable predatory behaviour towards living organisms

    C. Zhao, M. Zhu, Y. Fang, X. Liu, L. Wang, D. Chen and X. Huang, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C9MH00976K

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