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Self-mineralization and assembly of a bis-silylated Phe–Phe pseudodipeptide to a structured bioorganic–inorganic material

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Abstract

Self-mineralization of a trialkoxysilyl hybrid peptide yields in a single step a nanostructured hybrid material. A bis-silylated pseudodipeptide inspired from the Phe–Phe dipeptide was used to program the assembly by sol–gel polymerization under heterogeneous conditions, in water at pH 1.5 without any structure-directing agent. A mechanism deciphering the hybrid material assembly was proposed thanks to 1H NMR spectroscopy. First, water-insoluble hybrid building blocks were hydrolysed into their soluble silanol counterparts. Then, these transitional species, thanks to hydrogen bonding and π–π stacking, self-assembled in solution. Last, the proximity of the silanol moieties favoured their polycondensation into growing siloxane oligomers, which spontaneously precipitated to produce an ordered hybrid material.

Graphical abstract: Self-mineralization and assembly of a bis-silylated Phe–Phe pseudodipeptide to a structured bioorganic–inorganic material

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Publication details

The article was received on 16 Apr 2019, accepted on 03 Jul 2019 and first published on 08 Jul 2019


Article type: Communication
DOI: 10.1039/C9MH00580C
Mater. Horiz., 2019, Advance Article

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    Self-mineralization and assembly of a bis-silylated Phe–Phe pseudodipeptide to a structured bioorganic–inorganic material

    S. Jebors, L. Valot, C. Echalier, B. Legrand, R. Mikhaleff, A. Van Der Lee, R. Arenal, P. Dumy, M. Amblard, J. Martinez, A. Mehdi and G. Subra, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C9MH00580C

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