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Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment

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Abstract

We present a facile approach of a switchable polymer–gold nanoparticle, which programmatically co-delivers genes and chemical drugs (gene-chem). Between the delivery pathway and specific diseased cells the nanoparticle is switchable and allows for enhanced computed tomography (CT) imaging and synergistic neuronal recovery. The delivery system with precise conversion will serve as a powerful gene-chem co-delivery platform to enable accurate brain disease therapy.

Graphical abstract: Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment

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Publication details

The article was received on 29 Mar 2019, accepted on 06 Jun 2019 and first published on 22 Jun 2019


Article type: Communication
DOI: 10.1039/C9MH00482C
Mater. Horiz., 2019, Advance Article

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    Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment

    L. Liu, Y. Li, R. Liu, Q. Shen, Y. Li, Z. Shi, J. Shen, W. Ji and X. Zhang, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C9MH00482C

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