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Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

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Abstract

Here, Cu-TCPP MOF nanodots (denoted as CTMDs) were fabricated; they could functionally and structurally mimic the antioxidant superoxide diamutase (SOD) for alleviating endotoxemia with the ability of renal enrichment and clearance. CTMDs featured with a biomimetic size, a similar Cu active site coordination environment to that of natural SOD and ordered channels similar to substrate channels exhibited the highest SOD-like activity among other nanozymes. Together with the GPx-like activity, the bio-inspired CTMDs could protect cell components in vitro as well as reduce the systemic inflammation and mortality in an endotoxemia model in vivo.

Graphical abstract: Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

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Publication details

The article was received on 06 Mar 2019, accepted on 24 Apr 2019 and first published on 25 Apr 2019


Article type: Communication
DOI: 10.1039/C9MH00339H
Mater. Horiz., 2019, Advance Article

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    Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

    L. Zhang, Y. Zhang, Z. Wang, F. Cao, Y. Sang, K. Dong, F. Pu, J. Ren and X. Qu, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C9MH00339H

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