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Self-Assembled Nanomaterials: Design Principle, Nanostructural Effect, Functional Mechanism as Antimicrobial or Detection Agent

Abstract

Self-assembled nanomaterials are composed with building blocks through non-covalent interaction and spontaneously arranged into well-ordered nanostructures with defined functions. The well-organized arrangement and the two/three-dimension nanostructure of the architectures endow the nanomaterials abundant excellent biofunctions for antimicrobial applications and bacterial detections. Beyond nature inspired sources, the hybrid artificial nanomaterials including inorganic nanoparticles, nanosized small synthetic molecules assemblies, self-assembled multi-layer polymers are reviewed. We highlight recent contributions to developing strategies for the construction of self-assembled nanomaterials applied in bacterial infection. In addition, the design concept, assembled driving forces, nanostructural effect, bacterial targeting sites, stimuli-responsive factors, antimicrobial mechanism are also discussed and summarized. Especially, the relationship between the self-assembly and their biofunctions is emphasized. As the frontier field in supramolecular chemistry, in vivo self-assembled nanomaterials with specific stimuli-responsiveness and surprised biofunctions are also included in this review. Finally, we briefly outline our perspectives on how to explore and fabricate fascinated self-assembled nanomaterials and what the challenges are facing in this field

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Publication details

The article was received on 28 Dec 2018, accepted on 04 Feb 2019 and first published on 07 Feb 2019


Article type: Review Article
DOI: 10.1039/C8MH01670D
Citation: Mater. Horiz., 2019, Accepted Manuscript

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    Self-Assembled Nanomaterials: Design Principle, Nanostructural Effect, Functional Mechanism as Antimicrobial or Detection Agent

    H. Wang, L. Li, H. An, B. Peng and R. Zheng, Mater. Horiz., 2019, Accepted Manuscript , DOI: 10.1039/C8MH01670D

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