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A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

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Abstract

High-resolution imaging of lipids within the artery is of great value to obtain fundamental knowledge about their roles in atherosclerosis, but ideal probes are still lacking. In this study, we report a smart probe, namely, IND with aggregation-induced emission property for two-photon visualization of lipids within cell lines and arteries. Taking advantage of high lipid specificity, deep tissue penetrability, and excellent two-photon imaging performance, IND is capable of high-resolution imaging of lipids in cultured cells and in situ mapping of three-dimensional lipid distributions in mouse atherosclerotic plaques without tedious histological preparations. Importantly, we find that IND exhibits distinct emissive properties in the molecular monomer and dimer states; also, we uncover its remarkable applications for single-excitation dual-color imaging of lipid/water in the tissue microenvironment to reveal the ultra-structure of atherosclerotic plaques. The findings described herein provide a simple tool with minimal disruptive procedures for studying atherosclerosis at the tissue level and a powerful strategy for the development of imaging-based diagnostic techniques with color switching capability.

Graphical abstract: A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

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Publication details

The article was received on 13 Oct 2018, accepted on 22 Nov 2018 and first published on 23 Nov 2018


Article type: Communication
DOI: 10.1039/C8MH01293H
Citation: Mater. Horiz., 2019, Advance Article
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    A two-photon AIEgen for simultaneous dual-color imaging of atherosclerotic plaques

    B. Situ, M. Gao, X. He, S. Li, B. He, F. Guo, C. Kang, S. Liu, L. Yang, M. Jiang, Y. Hu, B. Z. Tang and L. Zheng, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C8MH01293H

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