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Issue 4, 2019
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Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy

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Abstract

A hybrid ‘clusterbomb’ as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to ‘bomb’ in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity.

Graphical abstract: Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy

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Article information


Submitted
12 Oct 2018
Accepted
16 Jan 2019
First published
26 Jan 2019

Mater. Horiz., 2019,6, 810-816
Article type
Communication

Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy

Q. Shen, J. Yang, R. Liu, L. Liu, J. Zhang, S. Shen and X. Zhang, Mater. Horiz., 2019, 6, 810
DOI: 10.1039/C8MH01286E

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