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Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy

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Abstract

A hybrid ‘clusterbomb’ as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to ‘bomb’ in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity.

Graphical abstract: Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy

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Publication details

The article was received on 12 Oct 2018, accepted on 16 Jan 2019 and first published on 26 Jan 2019


Article type: Communication
DOI: 10.1039/C8MH01286E
Citation: Mater. Horiz., 2019, Advance Article

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    Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy

    Q. Shen, J. Yang, R. Liu, L. Liu, J. Zhang, S. Shen and X. Zhang, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C8MH01286E

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