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Ratiometric immunoassays built from synergistic photonic absorption of size-diverse semiconducting MoS2 nanostructures

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Abstract

The intrinsic photonic properties of liquid-exfoliated (LE) MoS2 struggle extremely for the desired optical applications. Theoretical and experimental results briefly reveal that the broadband photonic absorption in LE MoS2 samples is ascribed to a synergistic mechanism, originated from layer-modulated electronic bandgaps and quantum confinement effects of ultra-small nanodots. Size fractionation of LE MoS2 is promoted with differential centrifugation, and narrowed size distributions of fractionated samples are identified. Tunable aggregation of LE MoS2 alters the distributions of the vertical and lateral dimensions, exhibiting ratiometric changes on photonic performances. With the integration of immunoassays, semiconducting MoS2 nano-probes with antibody modifications can linearly respond to specific targets, e.g. carcino-embryonic antigens, ranging from 5.0 to 180.0 ng mL−1, via ratiometric photonic absorption measurements. The nanostructured MoS2 optical ratiometric strategy exhibits a high repeatability, simple operation, low cost, and label-free characteristics, offering an alternative platform for practical immunoassays.

Graphical abstract: Ratiometric immunoassays built from synergistic photonic absorption of size-diverse semiconducting MoS2 nanostructures

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Publication details

The article was received on 30 Sep 2018, accepted on 19 Nov 2018 and first published on 27 Nov 2018


Article type: Communication
DOI: 10.1039/C8MH01232F
Citation: Mater. Horiz., 2019, Advance Article

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    Ratiometric immunoassays built from synergistic photonic absorption of size-diverse semiconducting MoS2 nanostructures

    B. L. Li, J. Wang, Z. F. Gao, H. Shi, H. L. Zou, K. Ariga and D. T. Leong, Mater. Horiz., 2019, Advance Article , DOI: 10.1039/C8MH01232F

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