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Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly

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Abstract

An inducible protein assembly system is desirable for developing high-order biomolecular architectures with dynamic properties. Here we demonstrate the creation of molecular networks with distinct stress-relaxation behavior using metal-induced protein assembly—a process that involves the folding and reconstitution of a pair of split IgG-binding GB1 proteins. In addition, metal–ligand coordination within the protein networks exerted great influence over their viscoelastic properties. The resulting protein networks are self-healable, amenable to biochemical decoration via SpyTag/SpyCatcher chemistry, and compatible with 3D culture of fibroblasts. This study points to a simple and robust strategy for designing recombinant protein hydrogels with tunable biochemical and mechanical properties.

Graphical abstract: Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly

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Publication details

The article was received on 20 Feb 2019, accepted on 10 May 2019 and first published on 10 May 2019


Article type: Paper
DOI: 10.1039/C9ME00027E
Mol. Syst. Des. Eng., 2019, Advance Article

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    Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly

    Y. Cao, X. Wei, Y. Lin and F. Sun, Mol. Syst. Des. Eng., 2019, Advance Article , DOI: 10.1039/C9ME00027E

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