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Elastin-like polypeptides as building motifs toward designing functional nanobiomaterials

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Abstract

Taking inspiration from naturally-occurring proteins, scientists have created protein polymers consisting of functional amino acid sequences that have evolved in nature. The functions of protein polymers can be custom-designed through the modular assembly of protein domains or minimized functional motifs. Elastin-like polypeptides (ELPs) are one of the exquisite building motifs in designing protein polymers. They exhibit stimuli-responsive self-assembling properties, remarkable elasticity, and favorable biological characteristics such as low platelet adhesion and low immunogenicity. With these characteristics, ELP-based materials have been demonstrated to be promising candidates for nanobiomaterial applications such as tissue engineering, drug delivery, and nanobiodevices. This review describes the recent developments in designing modular protein polymers containing ELPs as the building units.

Graphical abstract: Elastin-like polypeptides as building motifs toward designing functional nanobiomaterials

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Publication details

The article was received on 07 Jan 2019, accepted on 06 Mar 2019 and first published on 07 Mar 2019


Article type: Review Article
DOI: 10.1039/C9ME00002J
Mol. Syst. Des. Eng., 2019, Advance Article

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    Elastin-like polypeptides as building motifs toward designing functional nanobiomaterials

    D. H. T. Le and A. Sugawara-Narutaki, Mol. Syst. Des. Eng., 2019, Advance Article , DOI: 10.1039/C9ME00002J

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