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Issue 2, 2019
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Strontium confinement in polyacrylic acid brushes: a soft nanoarchitectonics approach for the design of titania coatings with enhanced osseointegration

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Abstract

Polyacrylic acid (PAA) brushes synthesized by reversible addition fragment chain transfer (RAFT) polymerization on titania (TiO2) surfaces were applied for the surface confinement and slow delivery of strontium (Sr2+) ions during the osseointegration process on TiO2 surfaces. Sr2+ is an essential element in the bone remodeling cycle and has large potential for application in therapies for bone-related diseases and bone replacement. Sr2+ complexation to the carboxylate groups of PAA was demonstrated by XPS while Sr2+ release in media was studied by ICP-MS. The Sr2+ concentration was varied by preparing PAA brushes at two grafting densities. At the higher grafting density, the brushes offer more carboxyl groups for Sr2+ binding. The architecture of the brushes and the amount of Sr2+ is controlled by the density of polymer chains. The morphology and brush thickness were characterized by AFM and ellipsometry. The significant effects of PAA brush coated TiO2 complexing Sr2+ on osteoblast cells is shown. The use of PAA brushes for Sr2+ confinement restricts Sr2+ activity to the cells in direct contact with the TiO2 surface. Initial adhesion of osteoblast cells is superior on coatings with brushes compared to bare TiO2. Moreover, a rather rapid cell tissue formation is observed for the cells cultured on the brushes with higher Sr2+ content. Enhanced biocompatibility and osseoactivity is confirmed by an increased alkaline phosphatase activity.

Graphical abstract: Strontium confinement in polyacrylic acid brushes: a soft nanoarchitectonics approach for the design of titania coatings with enhanced osseointegration

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Publication details

The article was received on 15 Nov 2018, accepted on 08 Feb 2019 and first published on 08 Feb 2019


Article type: Paper
DOI: 10.1039/C8ME00089A
Citation: Mol. Syst. Des. Eng., 2019,4, 421-430

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    Strontium confinement in polyacrylic acid brushes: a soft nanoarchitectonics approach for the design of titania coatings with enhanced osseointegration

    D. Gregurec, N. Politakos, L. Yate and S. E. Moya, Mol. Syst. Des. Eng., 2019, 4, 421
    DOI: 10.1039/C8ME00089A

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