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Strontium Confinement in Polyacrylic acid brushes: A Soft Nanoarchitectonics Approach for the Design of Titania coatings with enhanced osseointegration

Abstract

Polyacrylic acid (PAA) brushes synthesized by Reversible Addition Fragment Chain Transfer (RAFT) polymerization on titania (TiO2) surface were applied for the surface confinement and slow delivery of strontium (Sr2+) ions during the osseointegration process on TiO2 surface. Sr2+ is an essential element in the bone remodeling cycle and has large perspective for application in therapies for bone-related diseases and bone replacement. Sr2+complexation to the carboxylate groups of PAA was demonstrated by XPS while Sr2+release in media was studied by ICP-MS. Sr2+ concentration was varied by preparing PAA brushes at two grafting densities. At the higher grafting density, brushes offer more carboxyl groups for Sr2+ binding. The architecture of the brush and the amount of Sr2+ is controlled by the density of polymer chains. Morphology and brush thickness were characterized with AFM and ellipsometry. Significant effect of PAA brush coated TiO2 complexing Sr2+ on osteoblast cells is shown. The use of PAA brushes for Sr2+ confinement restricts Sr2+ activity to the cells in direct contact with the TiO2 surface. Initial adhesion of osteoblast is superior on brush coatings compared to bare TiO2. Moreover, a rather rapid cell tissue formation is observed for the cells cultured on the brush with the higher Sr2+ content. Enhanced biocompatibility and osseoactivity is confirmed by an increased alkaline phosphatase activity.

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Publication details

The article was received on 15 Nov 2018, accepted on 08 Feb 2019 and first published on 08 Feb 2019


Article type: Paper
DOI: 10.1039/C8ME00089A
Citation: Mol. Syst. Des. Eng., 2019, Accepted Manuscript

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    Strontium Confinement in Polyacrylic acid brushes: A Soft Nanoarchitectonics Approach for the Design of Titania coatings with enhanced osseointegration

    D. Gregurec, N. Politakos, L. Yate and S. E. Moya, Mol. Syst. Des. Eng., 2019, Accepted Manuscript , DOI: 10.1039/C8ME00089A

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