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Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

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Abstract

Directing polymer self-assembly through noncovalent interactions is a powerful way to control the structure and function of nanoengineered materials. Dynamic hydrogen bonds are particularly useful for materials with structures that change over time or in response to specific stimuli. In the present work, we use the supramolecular association of urea moieties to manipulate the morphology, thermal response, and mechanical properties of soft polymeric hydrogels. Urea-terminated poly(isopropyl glycidyl ether)-b-poly(ethylene oxide)-b-poly(isopropyl glycidyl ether) ABA triblock copolymers were synthesized using controlled, anionic ring-opening polymerization and subsequent chain-end functionalization. Triblock copolymers with hydroxy end-groups were incapable of hydrogelation, while polymers terminated with meta-bis-urea motifs formed robust gels at room temperature. Rheometric analysis of the bulk gels, variable-temperature infrared spectroscopy (VT-IR), differential scanning calorimetry (DSC), and small-angle X-ray scattering (SAXS) confirmed the formation of structured hydrogels via association of the meta-bis-urea end-groups. Monourea end-groups did not result in the same regular structure as the meta-bis-urea. In future, the reported hydrogels could be useful for elastomeric, shape-morphing 3D-printed constructs, or as biomimetic scaffolds with precisely tailored porosity and mechanical properties.

Graphical abstract: Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

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Publication details

The article was received on 18 Sep 2018, accepted on 21 Nov 2018 and first published on 21 Nov 2018


Article type: Paper
DOI: 10.1039/C8ME00063H
Citation: Mol. Syst. Des. Eng., 2019, Advance Article
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    Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

    R. T. Shafranek, J. D. Leger, S. Zhang, M. Khalil, X. Gu and A. Nelson, Mol. Syst. Des. Eng., 2019, Advance Article , DOI: 10.1039/C8ME00063H

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