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Issue 12, 2019
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Preparation and clinical translation of 99mTc-PSMA-11 for SPECT imaging of prostate cancer

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Abstract

This study explores the feasibility of radiolabeling the HBED-CC-PSMA (PSMA-11) ligand with Tc-99m for SPECT imaging of prostate cancer patients. 68Ga-HBED-CC-PSMA (PSMA-11) is used clinically for PET/CT imaging of prostate cancer (PCa) patients. However, a PET/CT facility may not be affordable and/or accessible to remotely located health centers. Thus, economic considerations require development of a SPECT-based tracer to provide low cost effective health care to the entire global population. Hence, radiochemical parameters were varied and optimized to obtain the maximum radiochemical yield of 99mTc-PSMA-11. 99mTc-PSMA-11 could be prepared in 60 ± 5% radiochemical yield and >98% radiochemical purity with a specific activity of 15 ± 5 GBq μmol−1. The radiotracer exhibited high stability in vitro in human serum after 24 h. A cell uptake of 15.2 ± 1.2% was observed for 99mTc-PSMA-11 in PSMA-positive prostate carcinoma LNCaP cells. Rapid clearance from blood, liver, intestine, lungs and other major organs was observed during normal biodistribution studies. The radiotracer, 99mTc-PSMA-11, exhibited physiological distribution in salivary and lacrimal glands similar to that of 68Ga-PSMA-11 in mice and successfully identified primary tumors as well as metastatic lesions in human patients. This study thus highlights successful radiolabeling of HBED-CC-PSMA with Tc-99m and the potential of 99mTc-PSMA-11 as a SPECT imaging agent for PCa.

Graphical abstract: Preparation and clinical translation of 99mTc-PSMA-11 for SPECT imaging of prostate cancer

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Publication details

The article was received on 19 Aug 2019, accepted on 15 Oct 2019 and first published on 22 Nov 2019


Article type: Research Article
DOI: 10.1039/C9MD00401G
Med. Chem. Commun., 2019,10, 2111-2117

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    Preparation and clinical translation of 99mTc-PSMA-11 for SPECT imaging of prostate cancer

    K. Vats, K. Agrawal, R. Sharma, H. D. Sarma, D. Satpati and A. Dash, Med. Chem. Commun., 2019, 10, 2111
    DOI: 10.1039/C9MD00401G

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