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Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

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Abstract

Duramycin derivatives incorporating an [18F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential tracers for imaging of phosphatidylethanolamine during apoptosis. [18F]FP-digalacto-duramycin exhibited a low Log D, high renal clearance and low background activity and is a promising radiotracer for tracking apoptosis in vivo.

Graphical abstract: Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

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Publication details

The article was received on 09 Jul 2019, accepted on 11 Sep 2019 and first published on 25 Sep 2019


Article type: Research Article
DOI: 10.1039/C9MD00354A
Med. Chem. Commun., 2019, Advance Article

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    Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

    M. B. Haskali, D. Denoyer, P. D. Roselt, R. J. Hicks and C. A. Hutton, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00354A

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