Jump to main content
Jump to site search


Sirtuin inhibition and anti-cancer activities of ethyl 2-benzimidazole-5-carboxylate derivatives

Author affiliations

Abstract

New benzimidazoles were synthesized based on the previously identified sirtuin inhibitor BZD9L1. The compounds were screened for their sirtuin (SIRT1, SIRT2 and SIRT3) inhibitory activities. Compound BZD9Q1 was determined to be a pan-SIRT1–3 inhibitor. Furthermore, the proliferation of various cancer cells was inhibited by BZD9Q1. It was shown that BZD9Q1 elicits a cytostatic effect by inducing cell cycle arrest at the G2/M phase while also showing a prominent induction of apoptosis against oral cancer cells.

Graphical abstract: Sirtuin inhibition and anti-cancer activities of ethyl 2-benzimidazole-5-carboxylate derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Jun 2019, accepted on 28 Oct 2019 and first published on 18 Nov 2019


Article type: Research Article
DOI: 10.1039/C9MD00323A
Med. Chem. Commun., 2019, Advance Article

  •   Request permissions

    Sirtuin inhibition and anti-cancer activities of ethyl 2-benzimidazole-5-carboxylate derivatives

    K. Y. Yeong, M. I. H. Nor Azizi, N. Berdigaliyev, W. N. Chen, W. L. Lee, A. N. Shirazi and K. Parang, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00323A

Search articles by author

Spotlight

Advertisements