Jump to main content
Jump to site search


Emerging modes-of-action in drug discovery

Author affiliations

Abstract

An increasing focus on complex biology to cure diseases rather than merely treat symptoms has transformed how drug discovery can be approached. Instead of activating or blocking protein function, a growing repertoire of drug modalities can be leveraged or engineered to hijack cellular processes, such as translational regulation or degradation mechanisms. Drug hunters can therefore access a wider arsenal of modes-of-action to modulate biological processes and this review summarises these emerging strategies by highlighting the most representative examples of these approaches.

Graphical abstract: Emerging modes-of-action in drug discovery

Back to tab navigation

Publication details

The article was received on 08 May 2019, accepted on 21 Jun 2019 and first published on 25 Jun 2019


Article type: Review Article
DOI: 10.1039/C9MD00263D
Med. Chem. Commun., 2019, Advance Article

  •   Request permissions

    Emerging modes-of-action in drug discovery

    E. Valeur, F. Narjes, C. Ottmann and A. T. Plowright, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00263D

Search articles by author

Spotlight

Advertisements