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Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

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Abstract

The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations.

Graphical abstract: Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

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Publication details

The article was received on 07 May 2019, accepted on 10 Jul 2019 and first published on 12 Jul 2019


Article type: Research Article
DOI: 10.1039/C9MD00262F
Med. Chem. Commun., 2019, Advance Article

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    Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

    A. A. Nazarova, K. N. Sedenkova, D. S. Karlov, M. I. Lavrov, Y. K. Grishin, T. S. Kuznetsova, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina and V. A. Palyulin, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00262F

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