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Different solid forms for optimizing route of administration of the herpes drug Pritelivir

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Abstract

Pritelivir (AIC316, BAY 57-1293) was discovered as a highly potent drug against herpes simplex viruses with a novel mode of action, i.e. inhibition of the viral helicase–primase. A side by side comparison of the oral form against Valtrex™ in patients with genital herpes, showed superiority in phase II testing for Pritelivir. A number of different solid forms have been generated for additional, e.g. systemic, or topical applications.

Graphical abstract: Different solid forms for optimizing route of administration of the herpes drug Pritelivir

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Publication details

The article was received on 18 Apr 2019, accepted on 05 Aug 2019 and first published on 09 Aug 2019


Article type: Review Article
DOI: 10.1039/C9MD00233B
Med. Chem. Commun., 2019, Advance Article

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    Different solid forms for optimizing route of administration of the herpes drug Pritelivir

    H. Ruebsamen-Schaeff and H. Buschmann, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00233B

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