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Tailored therapeutics based on 1,2,3-1H-triazoles: A mini review


The contemporary drug discovery approaches rely on library synthesis coupled with combinatorial methods and high-throughput screening to identify the leads. However, due to a multitude of the components involved, majority of the optimization techniques face persistent challenges related to the efficiency of synthetic processes and the purity of compound libraries. These methods have recently find an upgradation as fragment-based approaches for target-guided synthesis of lead molecules with an active involvement of their biological target. Click chemistry approach serves as a promising tool for tailoring the therapeutically relevant biomolecules of interest, improving their bioavailability and bioactivity and redirecting them as efficacious drugs. 1,2,3-1H-triazole nucleus being a planar and biologically acceptable scaffold plays a crucial role in designing biomolecular mimetics and tailor-made molecules with therapeutic relevance. This versatile scaffold also forms an integral part of the current fragment based approaches for drug designing, kinetic target guided synthesis and bioorthogonal methodologies.

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Publication details

The article was received on 12 Apr 2019, accepted on 13 May 2019 and first published on 14 May 2019

Article type: Review Article
DOI: 10.1039/C9MD00218A
Med. Chem. Commun., 2019, Accepted Manuscript

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    Tailored therapeutics based on 1,2,3-1H-triazoles: A mini review

    P. PRASHER and M. Sharma, Med. Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9MD00218A

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