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Prodrug strategies for targeted therapy triggered by reactive oxygen species

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Abstract

Increased levels of reactive oxygen species (ROS) have been associated with numerous pathophysiological conditions including cancer and inflammation and the ROS stimulus constitutes a potential trigger for drug delivery strategies. Over the past decade, a number of ROS-sensitive functionalities have been identified with the purpose of introducing disease-targeting properties into small molecule drugs – a prodrug strategy that offers a promising approach for increasing the selectivity and efficacy of treatments. This review will provide an overview of the ROS-responsive prodrugs developed to date. A discussion on the current progress and limitations is provided along with a reflection on the unanswered questions that need to be addressed in order to advance this novel approach to the clinic.

Graphical abstract: Prodrug strategies for targeted therapy triggered by reactive oxygen species

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Publication details

The article was received on 20 Mar 2019, accepted on 03 May 2019 and first published on 08 May 2019


Article type: Review Article
DOI: 10.1039/C9MD00169G
Med. Chem. Commun., 2019, Advance Article

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    Prodrug strategies for targeted therapy triggered by reactive oxygen species

    J. Peiró Cadahía, V. Previtali, N. S. Troelsen and M. H. Clausen, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00169G

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