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Recent insights into natural product inhibitors of matrix metalloproteinases

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Abstract

Members of the matrix metalloproteinase (MMP) family have biological functions that are central to human health and disease, and MMP inhibitors have been investigated for the treatment of cardiovascular disease, cancer and neurodegenerative disorders. The outcomes of initial clinical trials with the first generation of MMP inhibitors proved disappointing. However, our growing understanding of the complexities of the MMP function in disease, and an increased understanding of MMP protein architecture and control of activity now provide new opportunities and avenues to develop MMP-focused therapies. Natural products that affect MMP activities have been of strong interest as templates for drug discovery, and for their use as chemical tools to help delineate the roles of MMPs that still remain to be defined. Herein, we highlight the most recent discoveries of structurally diverse natural product inhibitors to these proteases.

Graphical abstract: Recent insights into natural product inhibitors of matrix metalloproteinases

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Publication details

The article was received on 18 Mar 2019, accepted on 11 Sep 2019 and first published on 07 Oct 2019


Article type: Review Article
DOI: 10.1039/C9MD00165D
Med. Chem. Commun., 2019, Advance Article

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    Recent insights into natural product inhibitors of matrix metalloproteinases

    G. B. Kumar, B. G. Nair, J. J. P. Perry and D. B. C. Martin, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00165D

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