Issue 8, 2019

Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box

Abstract

A new class of piano-stool iridium complexes with 1,2-diaminoethane ligands are shown to be effective and safe antimicrobials with activity against Staphylococcus aureus, including various isolates of methicillin-resistant strains (MRSA). Comparison to other piano stool complexes with activity against mycobacteria are made along with a discussion of structure–activity relationships. The structures of one the most active complexes with the ligand cis-1,2-diaminocyclohexane and one of the least active complexes with the ligand trans-1,2-diaminocyclohexane are compared and discussed with respect to their drastically different activities. In vitro toxicity studies for all of the complexes are described. In addition, a mouse study with one of the complexes, [(pentamethylcyclopentadienyl)(cis-1,2-diaminocyclohexane)(chloro)iridium]chloride, showed no ill effects on the mice at high doses.

Graphical abstract: Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box

Supplementary files

Article information

Article type
Research Article
Submitted
07 Mar 2019
Accepted
09 May 2019
First published
14 May 2019

Med. Chem. Commun., 2019,10, 1391-1398

Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box

C. M. DuChane, G. W. Karpin, M. Ehrich, J. O. Falkinham and J. S. Merola, Med. Chem. Commun., 2019, 10, 1391 DOI: 10.1039/C9MD00140A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements