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Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

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Abstract

Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The development of inhibitors of the enzyme dihydrodipicolinate synthase (DHDPS), which is involved in the diaminopimelate pathway, represents an attractive approach to the discovery of new antibacterial agents. Herein, the challenges and opportunities of DHDPS inhibitors are discussed.

Graphical abstract: Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

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Publication details

The article was received on 21 Feb 2019, accepted on 04 Jul 2019 and first published on 15 Jul 2019


Article type: Review Article
DOI: 10.1039/C9MD00107G
Med. Chem. Commun., 2019, Advance Article

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    Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

    R. M. Christoff, C. K. Gardhi, T. P. Soares da Costa, M. A. Perugini and B. M. Abbott, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00107G

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