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Issue 5, 2019
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Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1

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Abstract

A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). An enzyme based assay demonstrated that 5-I-AMT is a substrate of IDO-1. The in vivo distribution and imaging potential of 5-I-AMT were explored with a B16F10 tumor model using I-124 as the radiotag.

Graphical abstract: Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1

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Publication details

The article was received on 07 Feb 2019, accepted on 11 Apr 2019 and first published on 15 Apr 2019


Article type: Research Article
DOI: 10.1039/C9MD00082H
Med. Chem. Commun., 2019,10, 814-816

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    Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1

    B. C. Giglio, H. Wang, X. Yan and Z. Li, Med. Chem. Commun., 2019, 10, 814
    DOI: 10.1039/C9MD00082H

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