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Issue 4, 2019
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Origin and bioactivities of thiosulfinated FK228

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During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.

Graphical abstract: Origin and bioactivities of thiosulfinated FK228

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Article information

31 Jan 2019
14 Mar 2019
First published
25 Mar 2019

Med. Chem. Commun., 2019,10, 538-542
Article type
Research Article

Origin and bioactivities of thiosulfinated FK228

X. Liu, G. C. Currens, L. Xue and Y. Cheng, Med. Chem. Commun., 2019, 10, 538
DOI: 10.1039/C9MD00060G

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