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Issue 4, 2019
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Origin and bioactivities of thiosulfinated FK228

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Abstract

During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel. Evidence supports the postulations that TS-FK228 was derived from FK228 through spontaneous chemical reaction with silica gel, and TS-FK228 existed as two isomers 1 and 2. TS-FK228 demonstrated similar inhibitory activity and profile against human class I histone deacetylases but exhibited a much higher antiproliferative activity against representative human cancer cell lines when compared to FK228.

Graphical abstract: Origin and bioactivities of thiosulfinated FK228

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Publication details

The article was received on 31 Jan 2019, accepted on 14 Mar 2019 and first published on 25 Mar 2019


Article type: Research Article
DOI: 10.1039/C9MD00060G
Citation: Med. Chem. Commun., 2019,10, 538-542

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    Origin and bioactivities of thiosulfinated FK228

    X. Liu, G. C. Currens, L. Xue and Y. Cheng, Med. Chem. Commun., 2019, 10, 538
    DOI: 10.1039/C9MD00060G

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