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Issue 3, 2019
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Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

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Abstract

Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as D/L diaminobutyric acid and D-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.

Graphical abstract: Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

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Publication details

The article was received on 17 Jan 2019, accepted on 20 Feb 2019 and first published on 12 Mar 2019


Article type: Research Article
DOI: 10.1039/C9MD00031C
Citation: Med. Chem. Commun., 2019,10, 484-487
  • Open access: Creative Commons BY license
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    Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

    R. D. Ballantine, C. E. McCallion, E. Nassour, S. Tokajian and S. A. Cochrane, Med. Chem. Commun., 2019, 10, 484
    DOI: 10.1039/C9MD00031C

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