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Issue 7, 2019
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Targeting S. mutans biofilms: a perspective on preventing dental caries

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Abstract

The prevalence of biofilm diseases, and dental caries in particular, have encouraged extensive research on S. mutans biofilms, including methods of preventing its formation. Numerous small molecules with specific anti-biofilm activity against this pathogen have been isolated and synthesized. Generally, these molecules can be characterized into three categories: sucrose-dependent anti-adhesion, sucrose-independent anti-adhesion and cellular signaling interference. This review aims to provide an overview of the current small molecule strategies used for targeting S. mutans biofilms, and a perspective of the future for the field.

Graphical abstract: Targeting S. mutans biofilms: a perspective on preventing dental caries

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Article information


Submitted
10 Jan 2019
Accepted
12 Mar 2019
First published
19 Mar 2019

Med. Chem. Commun., 2019,10, 1057-1067
Article type
Review Article
Author version available

Targeting S. mutans biofilms: a perspective on preventing dental caries

A. M. Scharnow, A. E. Solinski and W. M. Wuest, Med. Chem. Commun., 2019, 10, 1057
DOI: 10.1039/C9MD00015A

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