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Targeting S. mutans biofilms: a perspective on preventing dental caries

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Abstract

The prevalence of biofilm diseases, and dental caries in particular, have encouraged extensive research on S. mutans biofilms, including methods of preventing its formation. Numerous small molecules with specific anti-biofilm activity against this pathogen have been isolated and synthesized. Generally, these molecules can be characterized into three categories: sucrose-dependent anti-adhesion, sucrose-independent anti-adhesion and cellular signaling interference. This review aims to provide an overview of the current small molecule strategies used for targeting S. mutans biofilms, and a perspective of the future for the field.

Graphical abstract: Targeting S. mutans biofilms: a perspective on preventing dental caries

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 10 Jan 2019, accepted on 12 Mar 2019 and first published on 19 Mar 2019


Article type: Review Article
DOI: 10.1039/C9MD00015A
Citation: Med. Chem. Commun., 2019, Advance Article

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    Targeting S. mutans biofilms: a perspective on preventing dental caries

    A. M. Scharnow, A. E. Solinski and W. M. Wuest, Med. Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9MD00015A

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