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Issue 4, 2019
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Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel

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Abstract

Based on the scaffold of astemizole, three novel turn-on fluorescent probes (N1N3) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein. These probes have reasonable fluorescence properties, acceptable cell toxicity, and potent inhibitory activity, all of which contribute to cell imaging at the nanomolar level. Overall, these probes have the potential for setting up a screening system for hERG channels.

Graphical abstract: Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel

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Publication details

The article was received on 14 Nov 2018, accepted on 25 Feb 2019 and first published on 26 Feb 2019


Article type: Research Article
DOI: 10.1039/C8MD00562A
Citation: Med. Chem. Commun., 2019,10, 513-516

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    Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel

    X. Zhang, T. Liu, B. Wang, Y. Gao, P. Liu, M. Li and L. Du, Med. Chem. Commun., 2019, 10, 513
    DOI: 10.1039/C8MD00562A

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