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Origami-paper-based device for microvesicle/exosome preconcentration and isolation

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Abstract

Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.

Graphical abstract: Origami-paper-based device for microvesicle/exosome preconcentration and isolation

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Publication details

The article was received on 11 Aug 2019, accepted on 18 Oct 2019 and first published on 18 Oct 2019


Article type: Communication
DOI: 10.1039/C9LC00796B
Lab Chip, 2019, Advance Article

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    Origami-paper-based device for microvesicle/exosome preconcentration and isolation

    H. Kim, K. H. Lee, S. I. Han, D. Lee, S. Chung, D. Lee and J. H. Lee, Lab Chip, 2019, Advance Article , DOI: 10.1039/C9LC00796B

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