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Issue 23, 2019
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Origami-paper-based device for microvesicle/exosome preconcentration and isolation

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Abstract

Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.

Graphical abstract: Origami-paper-based device for microvesicle/exosome preconcentration and isolation

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Supplementary files

Article information


Submitted
11 Aug 2019
Accepted
18 Oct 2019
First published
18 Oct 2019

Lab Chip, 2019,19, 3917-3921
Article type
Communication

Origami-paper-based device for microvesicle/exosome preconcentration and isolation

H. Kim, K. H. Lee, S. I. Han, D. Lee, S. Chung, D. Lee and J. H. Lee, Lab Chip, 2019, 19, 3917
DOI: 10.1039/C9LC00796B

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