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Issue 20, 2019
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Microfluidic cap-to-dispense (μCD): a universal microfluidic–robotic interface for automated pipette-free high-precision liquid handling

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Abstract

Microfluidic devices have been increasingly used for low-volume liquid handling operations. However, laboratory automation of such delicate devices has lagged behind due to the lack of world-to-chip (macro-to-micro) interfaces. In this paper, we have presented the first pipette-free robotic–microfluidic interface using a microfluidic-embedded container cap, referred to as a microfluidic cap-to-dispense (μCD), to achieve a seamless integration of liquid handling and robotic automation without any traditional pipetting steps. The μCD liquid handling platform offers a generic and modular way to connect the robotic device to standard liquid containers. It utilizes the high accuracy and high flexibility of the robotic system to recognize, capture and position; and then using microfluidic adaptive printing it can achieve high-precision on-demand volume distribution. With its modular connectivity, nanoliter processability, high adaptability, and multitask capacity, μCD shows great potential as a generic robotic–microfluidic interface for complete pipette-free liquid handling automation.

Graphical abstract: Microfluidic cap-to-dispense (μCD): a universal microfluidic–robotic interface for automated pipette-free high-precision liquid handling

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Publication details

The article was received on 29 Jun 2019, accepted on 28 Aug 2019 and first published on 10 Sep 2019


Article type: Paper
DOI: 10.1039/C9LC00622B
Lab Chip, 2019,19, 3405-3415

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    Microfluidic cap-to-dispense (μCD): a universal microfluidic–robotic interface for automated pipette-free high-precision liquid handling

    J. Wang, K. Deng, C. Zhou, Z. Fang, C. Meyer, K. U. Deshpande, Z. Li, X. Mi, Q. Luo, B. D. Hammock, C. Tan, Y. Chen and T. Pan, Lab Chip, 2019, 19, 3405
    DOI: 10.1039/C9LC00622B

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