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Issue 17, 2019
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Biodegradable microcontainers – towards real life applications of microfabricated systems for oral drug delivery

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Abstract

Microfabrication techniques have been applied to develop micron-scale devices for oral drug delivery with a high degree of control over size, shape and material composition. Recently, microcontainers have been introduced as a novel approach to obtain unidirectional release to avoid luminal drug loss, enhance drug permeation, protect drug payload from the harsh environment of the stomach, and explore the ability for targeted drug delivery. However, in order to eventually pave the way for real life applications of these microfabricated drug delivery systems, it is necessary to fabricate them in biodegradable materials approved for similar applications and with strategies that potentially allow for large scale production. In this study, we for the first time evaluate biodegradable microcontainers for oral drug delivery. Asymmetric poly-ε-caprolactone (PCL) microcontainers with a diameter of 300 μm and a volume of 2.7 nL are fabricated with a novel single-step fabrication process. The microcontainers are loaded with the model drug paracetamol and coated with an enteric pH-sensitive Eudragit® S100 coating to protect the drug until it reaches the desired location in the small intestine. In vitro dissolution studies are performed to assess the drug load and release profile of the PCL microcontainers. Finally, in vivo studies in rats showed a higher bioavailability compared to conventional dosage forms and confirm the potential of biodegradable microcontainers for oral drug delivery.

Graphical abstract: Biodegradable microcontainers – towards real life applications of microfabricated systems for oral drug delivery

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Publication details

The article was received on 03 Jun 2019, accepted on 25 Jul 2019 and first published on 01 Aug 2019


Article type: Paper
DOI: 10.1039/C9LC00527G
Lab Chip, 2019,19, 2905-2914

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    Biodegradable microcontainers – towards real life applications of microfabricated systems for oral drug delivery

    Z. Abid, S. Strindberg, M. M. Javed, C. Mazzoni, L. Vaut, L. H. Nielsen, C. Gundlach, R. S. Petersen, A. Müllertz, A. Boisen and S. S. Keller, Lab Chip, 2019, 19, 2905
    DOI: 10.1039/C9LC00527G

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