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Issue 11, 2019
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Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing

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Abstract

Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free biosensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin–streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 × 103 molecules per μm2.

Graphical abstract: Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing

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Article information


Submitted
19 Feb 2019
Accepted
23 Apr 2019
First published
24 Apr 2019

Lab Chip, 2019,19, 1985-1990
Article type
Paper

Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing

L. Kelemen, E. Lepera, B. Horváth, P. Ormos, R. Osellame and R. Martínez Vázquez, Lab Chip, 2019, 19, 1985
DOI: 10.1039/C9LC00174C

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