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On-the-fly Exchangeable Microfluidic Nozzles for Facile Production of Various Monodisperse Micromaterials

Abstract

Micrometer-sized materials are key components for many life science applications including drug delivery, tissue engineering, and (bio)chemical purification methods. Microfluidic manufacturing platforms have advanced the production of micromaterials that are shape controlled, monodisperse, and chemically defined. Although different types of micromaterials can be microfluidically produced, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. To address this challenge, we here present an on-the-fly exchangeable nozzle concept that operates in a fully transparent, 3D, and reusable microfluidic device produced without cleanroom technology. The facile exchange and auto-repositioning of the nozzles readily enables the assembly of various distinct micromaterial production devices. Based on this principle, a single microfluidic device is engineered that produces oil-in-water and water-in-oil emulsions, solid and core-shell microspheres, microfibers, and even Janus type micromaterials with diameters ranging from 10 µm to 1000 µm and with monodisperse size distributions (CV<5%). Furthermore, the multifunctional 3D microfluidic device can be fabricated without any cleanroom technology and is based on widely available materials and techniques, which advances the widespread use of this universal micromaterial production platform.

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Publication details

The article was received on 16 Jan 2019, accepted on 13 Apr 2019 and first published on 16 Apr 2019


Article type: Paper
DOI: 10.1039/C9LC00054B
Citation: Lab Chip, 2019, Accepted Manuscript

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    On-the-fly Exchangeable Microfluidic Nozzles for Facile Production of Various Monodisperse Micromaterials

    T. Kamperman, B. van Loo, M. Gurian, S. Henke, M. Karperien and J. Leijten, Lab Chip, 2019, Accepted Manuscript , DOI: 10.1039/C9LC00054B

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