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A novel electromagnet-triggered pillar valve and its application in immunoassay on centrifugal platform

Abstract

The lab-on-a-disc is a powerful microfluidic platform that skillfully takes advantages of centrifugal force to controllable drive liquids with the assistance of passive or active valves. However, the passive valves are mainly triggered by the rotation speed and can be easily influenced by surface chemistry of the channel, while the active valves usually require complicated fabrication or actuation procedure. In this study, a novel active valve that can be easily triggered by an electromagnet was proposed and applied in the centrifugation platform. This valve, named as electromagnet-triggered pillar (ETP) valve, is consisted with a metal pin and a pressure sensitive adhesive (PSA) tape, which is closed until the pin is lifted up by an electromagnet to partially separate the PSA tape from the substrate. As a typical application, this valve is utilized to construct a centrifugal chip for mycotoxin detection. With four ETP valves in a unit, sample and liquid reagents can be sequentially released into the reaction chamber that spotted with mycotoxin conjugates to accomplish the whole immunoassay. Four mycotoxins (aflatoxin B1, ochratoxin A, T-2 toxin, and zearalenone) were simultaneously detected on this chip with the limit of detections that lower than the permissible limits set by the regulatory agencies of China, demonstrating the practicabiliFty of this easy-to-use active valve.

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Publication details

The article was received on 11 Jan 2019, accepted on 13 Apr 2019 and first published on 15 Apr 2019


Article type: Communication
DOI: 10.1039/C9LC00043G
Citation: Lab Chip, 2019, Accepted Manuscript

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    A novel electromagnet-triggered pillar valve and its application in immunoassay on centrifugal platform

    Y. Chen, M. Shen, Y. Zhu and Y. Xu, Lab Chip, 2019, Accepted Manuscript , DOI: 10.1039/C9LC00043G

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