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Issue 9, 2019
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A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

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Abstract

A small, consumable-free, low-power, ultra-high-speed comprehensive GC×GC system consisting of microfabricated columns, nanoelectromechanical system (NEMS) cantilever resonators for detection, and a valve-based stop-flow modulator is demonstrated. The separation of a highly polar 29-component mixture covering a boiling point range of 46 to 253 °C on a pair of microfabricated columns using a Staiger valve manifold in less than 7 seconds, and just over 4 seconds after the ensemble holdup time is demonstrated with a downstream FID. The analysis time of the second dimension was 160 ms, and peak widths in the second dimension range from 10–60 ms. A peak capacity of just over 300 was calculated for a separation of just over 6 s. Data from a continuous operation testing over 40 days and 20 000 runs of the GC×GC columns with the NEMS resonators using a 4-component test set is presented. The GC×GC-NEMS resonator system generated second-dimension peak widths as narrow as 8 ms with no discernable peak distortion due to under-sampling from the detector.

Graphical abstract: A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

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Article information


Submitted
09 Jan 2019
Accepted
18 Mar 2019
First published
18 Mar 2019

Lab Chip, 2019,19, 1633-1643
Article type
Paper
Author version available

A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

J. J. Whiting, E. Myers, R. P. Manginell, M. W. Moorman, J. Anderson, C. S. Fix, C. Washburn, A. Staton, D. Porter, D. Graf, D. R. Wheeler, S. Howell, J. Richards, H. Monteith, K. E. Achyuthan, M. Roukes and R. J. Simonson, Lab Chip, 2019, 19, 1633
DOI: 10.1039/C9LC00027E

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