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Issue 4, 2019
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A microfluidic platform integrated with field-effect transistors for enumeration of circulating tumor cells

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Abstract

Circulating tumor cells (CTCs) are one of the promising cancer biomarkers whose concentrations are measured not only in the initial diagnostic stages, but also as treatment progresses. However, the existing methods for CTC detection are relatively time-consuming and labor-intensive. In this study, a new microfluidic platform integrated with field-effect transistors (FETs) and chambers for the trapping of CTCs was developed. This novel design could not only trap CTCs from whole blood samples, but also enumerate them via FET sensing of CTC-specific aptamer–CTC complexes. The FET output signal was experimentally found to increase with the increasing number of captured CTCs. More importantly, the enumeration of spiked CTCs in blood samples could be achieved in accordance with the signals measured on the FET devices. We therefore believe that this automated system could be a useful tool for enumeration of CTCs.

Graphical abstract: A microfluidic platform integrated with field-effect transistors for enumeration of circulating tumor cells

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Publication details

The article was received on 09 Oct 2018, accepted on 04 Jan 2019 and first published on 07 Jan 2019


Article type: Paper
DOI: 10.1039/C8LC01072B
Citation: Lab Chip, 2019,19, 618-625

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    A microfluidic platform integrated with field-effect transistors for enumeration of circulating tumor cells

    Y. Chen, A. K. Pulikkathodi, Y. Ma, Y. Wang and G. Lee, Lab Chip, 2019, 19, 618
    DOI: 10.1039/C8LC01072B

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