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Issue 5, 2019
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Dual-phone illumination-imaging system for high resolution and large field of view multi-modal microscopy

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Abstract

In this paper we present for the first time a system comprised of two mobile phones, one for illumination and the other for microscopy, as a portable, user-friendly, and cost-effective microscopy platform for a wide range of applications. Versatile and adaptive illumination is made with a Retina display of an Apple mobile phone device. The phone screen is used to project various illumination patterns onto the specimen being imaged, each corresponding to a different illumination mode, such as bright-field, dark-field, point illumination, Rheinberg illumination, and fluorescence microscopy. The second phone (a Nokia phone) is modified to record microscopic images about the sample. This imaging platform provides a high spatial resolution of at least 2 μm, a large field-of-view of 3.6 × 2.7 mm, and a working distance of 0.6 mm. We demonstrate the performance of this platform for the visualization of microorganisms within microfluidic devices to gather qualitative and quantitative information regarding microorganism morphology, dimension, count, and velocity/trajectories in the xy plane.

Graphical abstract: Dual-phone illumination-imaging system for high resolution and large field of view multi-modal microscopy

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Publication details

The article was received on 20 Sep 2018, accepted on 05 Dec 2018 and first published on 30 Jan 2019


Article type: Paper
DOI: 10.1039/C8LC00995C
Lab Chip, 2019,19, 825-836
  • Open access: Creative Commons BY-NC license
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    Dual-phone illumination-imaging system for high resolution and large field of view multi-modal microscopy

    S. Kheireddine, A. Sudalaiyadum Perumal, Z. J. Smith, D. V. Nicolau and S. Wachsmann-Hogiu, Lab Chip, 2019, 19, 825
    DOI: 10.1039/C8LC00995C

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