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A continuous-flow acoustofluidic cytometer for single-cell mechanotyping

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Abstract

The biophysical properties of cells such as their compressibility have been found to be closely related to disease progression such as cancer development and metastasis. As cancer cells are heterogeneous, rapid and high-throughput evaluation of cell biophysical properties at single-cell resolution is needed to assess their potential as biomarkers for cancer staging and prognosis. Acoustofluidics has shown promise as a contactless method for accurately measuring cell biophysical properties; however, previously reported methods had relatively low throughput due to their requirement of no-flow conditions. This work presents a high-throughput continuous flow-based acoustofluidic cell mechanotyping method at single-cell resolution that retains the advantage of simplicity and low-cost.

Graphical abstract: A continuous-flow acoustofluidic cytometer for single-cell mechanotyping

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Publication details

The article was received on 09 Jul 2018, accepted on 07 Jan 2019 and first published on 10 Jan 2019


Article type: Communication
DOI: 10.1039/C8LC00711J
Citation: Lab Chip, 2019, Advance Article
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    A continuous-flow acoustofluidic cytometer for single-cell mechanotyping

    H. Wang, Z. Liu, D. M. Shin, Z. G. Chen, Y. Cho, Y. Kim and A. Han, Lab Chip, 2019, Advance Article , DOI: 10.1039/C8LC00711J

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