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Elemental mapping of biodegradable magnesium-based implants in bone and soft tissue by means of μ X-ray fluorescence analysis

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Abstract

Besides the biocompatibility and potential support of bone-healing, homogeneous degradation and the uniform distribution of degradation products are key factors for a successful medical application of magnesium (Mg)-based materials as biodegradable implants in orthopedic therapies. In this study, the elemental analysis of implant material, degradation products and mineralization progression was performed utilizing microbeam X-ray fluorescence spectrometry (μXRF). The specimens were derived from an in vivo mice study investigating the performance of Mg-based intramedullary nails in a fracture model. The observation of implant elements Mg and silver (Ag) together with bone-related elements calcium (Ca) and phosphorus (P) elucidated degradation and bone growth at the implant–tissue interface. Persistent parts of the nails were shown up to 133 days after implantation. Additionally the impact of the implanted Mg material on the macro-element balance in major elimination organs and muscles was analyzed by μXRF in comparison to a steel implant. An increase in the potassium level and a decrease in the calcium level were detected. The feasibility of utilizing elemental analysis as a bioimaging tool could be demonstrated.

Graphical abstract: Elemental mapping of biodegradable magnesium-based implants in bone and soft tissue by means of μ X-ray fluorescence analysis

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Publication details

The article was received on 02 Nov 2018, accepted on 21 Dec 2018 and first published on 08 Jan 2019


Article type: Paper
DOI: 10.1039/C8JA00377G
Citation: J. Anal. At. Spectrom., 2019, Advance Article
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    Elemental mapping of biodegradable magnesium-based implants in bone and soft tissue by means of μ X-ray fluorescence analysis

    H. Helmholz, B. J. C. Luthringer-Feyerabend and R. Willumeit-Römer, J. Anal. At. Spectrom., 2019, Advance Article , DOI: 10.1039/C8JA00377G

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