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Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones

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Abstract

A novel carbonylation of C(sp3)–H bonds in pyridylamines with one atmosphere of CO2 is reported to synthesize important pyrimidinones in good yields. This transition-metal-free and redox-neutral process features the use of a nontoxic carbonyl source, broad substrate scope, good functional group tolerance, facile scalability and easy product derivatization.

Graphical abstract: Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones

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Publication details

The article was received on 24 Oct 2019, accepted on 27 Nov 2019 and first published on 28 Nov 2019


Article type: Communication
DOI: 10.1039/C9GC03659H
Green Chem., 2019, Advance Article

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    Transition-metal-free lactamization of C(sp3)–H bonds with CO2: facile generation of pyrido[1,2-a]pyrimidin-4-ones

    Z. Zhang, X. Zhou, J. Wu, L. Song and D. Yu, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC03659H

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