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Palladium-catalyzed oxidative aminocarbonylation of alkynone O-methyloximes with simple amines in PEG-400

Abstract

A palladium-catalyzed oxidative aminocarbonylation of O- methyloximes and simple amines under aerobic conditions with PEG-400 as environmentally benign media was accomplished. This novel protocol provides the first straightforward synthetic method for the assembly of structurally diverse 4-carboxamide isoxazoles with high atom- and step-economy and exceptional functional group tolerance. Notably, the employment of ionic liquids as additive, with air as the sole oxidant, without ligands are some of the attractive features of the present approach.

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Publication details

The article was received on 15 Oct 2019, accepted on 02 Dec 2019 and first published on 03 Dec 2019


Article type: Paper
DOI: 10.1039/C9GC03562A
Green Chem., 2019, Accepted Manuscript

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    Palladium-catalyzed oxidative aminocarbonylation of alkynone O-methyloximes with simple amines in PEG-400

    J. Li, J. Yu, W. Xiong, H. Tang, M. Hu, W. Wu and H. Jiang, Green Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9GC03562A

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