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Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

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Abstract

Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp2)–N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (SNAr) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.

Graphical abstract: Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

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Publication details

The article was received on 01 Oct 2019, accepted on 11 Nov 2019 and first published on 12 Nov 2019


Article type: Communication
DOI: 10.1039/C9GC03410B
Green Chem., 2019, Advance Article

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    Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

    P. D. Q. Dao, H. Lim and C. S. Cho, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC03410B

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