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Issue 22, 2019
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Visible-light-mediated metal-free decarboxylative acylations of isocyanides with α-oxocarboxylic acids and water leading to α-ketoamides

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Abstract

An efficient visible-light-promoted approach for preparing α-ketoamides from α-oxocarboxylic acids, isocyanides and water is disclosed. The present transformation could be achieved under mild and metal-free conditions through a sequence of decarboxylation, radical addition and hydration processes, which provides a novel and facile route to construct α-ketoamides from simple and readily available chemical feedstocks.

Graphical abstract: Visible-light-mediated metal-free decarboxylative acylations of isocyanides with α-oxocarboxylic acids and water leading to α-ketoamides

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Publication details

The article was received on 16 Sep 2019, accepted on 14 Oct 2019 and first published on 14 Oct 2019


Article type: Communication
DOI: 10.1039/C9GC03253C
Green Chem., 2019,21, 6051-6055

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    Visible-light-mediated metal-free decarboxylative acylations of isocyanides with α-oxocarboxylic acids and water leading to α-ketoamides

    Y. Lv, P. Bao, H. Yue, J. Li and W. Wei, Green Chem., 2019, 21, 6051
    DOI: 10.1039/C9GC03253C

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