Yufen Lv, Pengli Bao, Huilan Yue, Jiang-Sheng Li and Wei Wei
Green Chem., 2019,21, 6051-6055
DOI:
10.1039/C9GC03253C,
Communication
An efficient visible-light-promoted approach for preparing α-ketoamides from α-oxocarboxylic acids, isocyanides and water is disclosed. The present transformation could be achieved under mild and metal-free conditions through a sequence of decarboxylation, radical addition and hydration processes, which provides a novel and facile route to construct α-ketoamides from simple and readily available chemical feedstocks.