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Diastereoselective synthesis of CF3-oxazinoquinolines in water

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Abstract

A highly efficient stereoselective synthesis of CF3-oxazinoquinolines was elaborated using the reaction of CF3-ynones with quinolines in water. It was demonstrated that under these green conditions, the reaction proceeds up to 20 times faster to provide target compounds in almost quantitative yields. Moreover, this method is devoid of any chromatographic purification to give CF3-oxazinoquinolines with complete diastereoselectivity. The presented eco-friendly approach was found much more efficient than standard reactions in organic solvents. The synthetic utility of the prepared CF3-oxazinoquinolines was demonstrated.

Graphical abstract: Diastereoselective synthesis of CF3-oxazinoquinolines in water

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Publication details

The article was received on 29 Aug 2019, accepted on 14 Oct 2019 and first published on 16 Oct 2019


Article type: Paper
DOI: 10.1039/C9GC03044A
Green Chem., 2019, Advance Article

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    Diastereoselective synthesis of CF3-oxazinoquinolines in water

    V. M. Muzalevskiy, K. V. Belyaeva, B. A. Trofimov and V. G. Nenajdenko, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC03044A

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