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Rapid Access to Cinnamamides and Piper Amides via Three Component Coupling of Arylaldehyde, Amines, and Meldrum’s Acid

Abstract

A practical method for the synthesis of cinnamamides and piper amides via a conceptually novel three component reaction of aldehydes, amines and Meldrum’s acid has been reported. The reaction proceeds under operationally simple conditions without the aid of coupling reagents, oxidants, or catalysts, which are essential for the preparation of cinnamamides/piper amides via known methods. The formation of undesired chemical wastes that are generally originated from the use of coupling reagents, oxidants, or catalysts has been avoided to make this reaction more atom economical.

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Publication details

The article was received on 20 Aug 2019, accepted on 30 Sep 2019 and first published on 01 Oct 2019


Article type: Communication
DOI: 10.1039/C9GC02937K
Green Chem., 2019, Accepted Manuscript

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    Rapid Access to Cinnamamides and Piper Amides via Three Component Coupling of Arylaldehyde, Amines, and Meldrum’s Acid

    S. Ghosh and C. K. Jana, Green Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9GC02937K

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