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The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions

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Abstract

A practical and sustainable protocol for the clean preparation of various multisubstituted pyrroles through an iodine-catalyzed multicomponent reaction under metal- and solvent-free conditions was developed. In the gram-scale synthesis, the desired pyrroles can be easily isolated in high-purity through simple extraction.

Graphical abstract: The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions

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Publication details

The article was received on 29 Jul 2019, accepted on 21 Oct 2019 and first published on 29 Nov 2019


Article type: Paper
DOI: 10.1039/C9GC02657F
Green Chem., 2019, Advance Article

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    The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions

    Q. Gui, X. He, W. Wang, H. Zhou, Y. Dong, N. Wang, J. Tang, Z. Cao and W. He, Green Chem., 2019, Advance Article , DOI: 10.1039/C9GC02657F

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